Role of core circadian clock genes in hormone release and target tissue sensitivity in the reproductive axis

Precise timing in hormone release from the hypothalamus, pituitary, and ovary is critical for fertility.

• The hypothalamic-pituitary-gonadal (HPG) axis regulates hormonal release patterns through a feedback loop.
• Circadian clocks in various reproductive tissues influence the timing and rhythmicity of hormone release.
• Molecular clock transcription factors are involved in generating cell-specific rhythms that affect hormone patterns.
• The review emphasizes the role of circadian rhythms in the female hypothalamus and pituitary on fertility outcomes.

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