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Corticotropin-releasing hormone activates connexin 43 via activator protein-1 transcription factor in human myometrial smooth muscle cells
Stress hormone triggers cell communication protein through a gene regulator in human uterine muscle cells
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Abstract
CRH significantly increased mRNA and protein expression of Cx43 in a dose-dependent manner (P < 0.01).
- CRH facilitated Cx43 expression and enhanced AP-1 promoter activity in human uterine smooth muscle cells.
- After CRH treatment, Cx43 expression in the cytoplasm increased significantly.
- The increase in Cx43 expression was linked to the upregulation of c-Fos expression.
- Blocking AP-1 sites on the Cx43 promoter nearly completely abolished the CRH-induced enhancement of Cx43 expression.
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