Members of the crustacean hyperglycemic hormone (CHH) peptide family are differentially distributed both between and within the neuroendocrine organs ofCancercrabs: implications for differential release and pleiotropic function

Aug 5, 2006The Journal of experimental biology

Different types of stress hormones are spread unevenly in crab hormone organs, suggesting varied release and multiple roles

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Differential distributions of crustacean hyperglycemic hormone (CHH) family peptides were observed in the neuroendocrine organs of seven crab species.

CHH, moult-inhibiting hormone (MIH), and other related peptides were mapped in various neuroendocrine sites across seven Cancer species.
The X-organ-sinus gland (XO-SG) contained CHH, CHH precursor-related peptide (CPRP), MIH, and mandibular organ-inhibiting hormone (MOIH).
The pericardial organ (PO) showed the presence of CHH, CPRP, and MOIH, while only MOIH was detected in the anterior cardiac plexus (ACP).
No immunolabeling was found in the anterior commissural organ (ACO).
In Cancer productus, and likely in all species studied, distinct sets of neurons housed different combinations of these peptides within the XO-SG and PO.
This suggests that the release of these peptides may respond to specific cues within the body, indicating potential functional diversity.

AI simplified

The crustacean hyperglycemic hormone (CHH) family of peptides includes CHH, moult-inhibiting hormone (MIH) and mandibular organ-inhibiting hormone (MOIH). In the crab Cancer pagurus, isoforms of these peptides, as well as CHH precursor-related peptide (CPRP), have been identified in the X-organ-sinus gland (XO-SG) system. Using peptides isolated from the C. pagurus SG, antibodies to each family member and CPRP were generated. These sera were then used to map the distributions and co-localization patterns of these peptides in the neuroendocrine organs of seven Cancer species: Cancer antennarius, Cancer anthonyi, Cancer borealis, Cancer gracilis, Cancer irroratus, Cancer magister and Cancer productus. In addition to the XO-SG, the pericardial organ (PO) and two other neuroendocrine sites contained within the stomatogastric nervous system, the anterior cardiac plexus (ACP) and the anterior commissural organ (ACO), were studied. In all species, the peptides were found to be differentially distributed between the neuroendocrine sites in conserved patterns: i.e. CHH, CPRP, MIH and MOIH in the XO-SG, CHH, CPRP and MOIH in the PO, and MOIH in the ACP (no immunolabeling was found in the ACO). Moreover, in C. productus (and probably in all species), the peptides present in the XO-SG and PO were differentially distributed between the neurons within each of these neuroendocrine organs (e.g. CHH and CPRP in one set of XO somata with MIH and MOIH co-localized in a different set of cell bodies). Taken collectively, the differential distributions of CHH family members and CPRP both between and within the neuroendocrine organs of crabs of the genus Cancer suggests that each of these peptides may be released into the circulatory system in response to varied, tissue-specific cues and that the PO- and/or ACP-derived isoforms may possess functions distinct from those classically ascribed to their release from the SG.

Full Text

Full text is available at the source.

View full text (PDF) ↗View full text ↗

Members of the crustacean hyperglycemic hormone (CHH) peptide family are differentially distributed both between and within the neuroendocrine organs ofCancercrabs: implications for differential release and pleiotropic function

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief