Cryptochrome-dependent circadian periods in the arcuate nucleus

Nov 7, 2015Neuroscience letters

Body clock rhythms in the brain's hunger control area depend on cryptochrome proteins

AI simplified

Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Cry1(-/-) mice exhibited period shortening, while Cry2(-/-) mice showed period lengthening in circadian rhythms compared to wild-type mice.

  • Circadian rhythms were analyzed by measuring PER2::LUCIFERASE expression in the suprachiasmatic nucleus (SCN) and arcuate nucleus (ARC).
  • Both the SCN and ARC showed altered periods in Cry1(-/-) and Cry2(-/-) mice, indicating genetic influence on circadian timing.
  • The ARC exhibited circadian period lengths identical to those of the SCN in both Cry1(-/-) and Cry2(-/-) mice.
  • PER2::LUC amplitudes in the ARC were reduced in all genotypes when compared to the SCN, suggesting differences in rhythm strength.
  • These findings indicate that the ARC may serve as a circadian pacemaker outside of the SCN.

AI simplified

Full Text

Full text is available at the source.
View full text (XML) ↗View full text ↗

Related papers

Mar '16
Lithium's effects on daily biological rhythms in skin cells and brain clock tissue from mice lacking Cry genes
cited by 27 papers
research support, n.i.h., extramural
Jun '12
Different roles of internal clock genes in the eye's rhythm system and the brain's master clock
top 30% journal
cited by 47 papers
research support, n.i.h., extramural
Jul '15
Specific Ion Channels Control Daily Timing of a Key Protein in the Brain’s Biological Clock
cited by 22 papers
research support, n.i.h., extramural
Apr '17
Interaction Between the Brain's Internal Clock and Metabolic Control Areas Needed to Organize Body Rhythms
top 20% journal
cited by 73 papers
research support, non-u.s. gov't
Feb '10
Food anticipation behavior in mice lacking internal clock genes: confirming known patterns and identifying new ones
top 20% journal
cited by 37 papers
comparative study
Oct '15
Daily activity patterns in the smell-processing area of moving mice depend on the brain’s master clock but not on their behavior rhythms
cited by 18 papers
research support, non-u.s. gov't
Dec '12
Daily rhythms in Cry1-deficient mice depend on communication within the brain’s circadian center
cited by 34 papers
research support, n.i.h., extramural
Apr '13
Cryptochromes are essential for clear daily rhythms in the mouse brain's internal clock
top 2% journal
cited by 100 papers
research support, non-u.s. gov't
Feb '17
Two sources of daily calcium rhythms inside cells of the brain’s biological clock
top 20% journal
cited by 51 papers
research support, non-u.s. gov't

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #30
Your hair can reveal your circadian rhythm from a single sample
1 week ago7 studies
issue #29
Your body clock needs 25% more epidural painkiller at night
2 weeks ago7 studies
issue #28
Night owls have 123% higher mortality risk after age 81
3 weeks ago7 studies
issue #27
Light pollution linked to 31% higher diabetes risk in major analysis
4 weeks ago7 studies
issue #26
Wearables can detect early dementia signs with 70-95% accuracy across 200,000+ people
5 weeks ago7 studies
issue #25
Your brain's master clock has 7 distinct neuron types with specific jobs
6 weeks ago7 studies
issue #24
Sleep disruption in teens linked to altered circadian gene expression and future heart disease risk
7 weeks ago7 studies
issue #23
Morning-loaded eating suppresses ghrelin more than evening meals — and artificial light disrupts immune rhythms in wild rodents
8 weeks ago7 studies
issue #22
Evening people have 83% higher depression risk, while gut bacteria shape your body clock
9 weeks ago7 studies
issue #21
Social jetlag linked to teen depression, while dairy-rich breakfasts improve blood sugar in diabetes
10 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief