Lion's Mane Mushroom Root May Reduce the Risk of Ketamine Abuse

Higher doses of H. erinaceus mycelium and erinacine A significantly reduced ketamine intake and motivation in a rat self-administration model.

• H. erinaceus mycelium and erinacine A were tested in relation to ketamine's potential for abuse.
• Both compounds decreased the amount of ketamine that rats chose to self-administer.
• The reduction in ketamine consumption occurred under both fixed and progressive reinforcement schedules.
• Unlike ketamine, H. erinaceus mycelium did not affect the consumption of food rewards.
• Erinacine A was associated with a decrease in food reinforcement, indicating a different effect profile.

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