Carbohydrate polymersJul 23, 2026

Recent progress and potential treatments using cyclodextrin to deliver resveratrol

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Jul 24, 2026

Abstract

Cyclodextrins may enhance the solubility and stability of resveratrol.

Resveratrol is associated with antioxidant, anti-inflammatory, anticancer, and cardioprotective properties but faces challenges like low solubility and bioavailability.
Inclusion complexes formed with cyclodextrins can potentially improve the therapeutic efficacy of resveratrol.
Advanced delivery platforms, including cyclodextrin-based nanosponges and hybrid nanosystems, have shown encouraging results in enhancing biological activity.
The review discusses the mechanisms that may improve the bioavailability of resveratrol through cyclodextrin interactions.
Current challenges and future perspectives of cyclodextrin-enabled strategies for resveratrol delivery are outlined.

Simplified

Resveratrol (RES) is a naturally occurring polyphenol with established antioxidant, anti-inflammatory, anticancer, and cardioprotective properties. However, low aqueous solubility, poor chemical stability, fast metabolism, and low oral bioavailability severely restrict its clinical translation. Cyclodextrins (CDs) and their derivatives, which act as host molecules, can be improved the solubility, stability, and therapeutic efficacy of RES by formation inclusion complexes (ICs). In addition to conventional CDs/RES ICs, various advanced delivery platforms, including CDs-based nanosponges, hybrid nanosystems, and topical/transdermal formulations have demonstrated encouraging outcomes in recent years in terms of enhancing biological activity and modifying release kinetics. Accordingly, a comprehensive understanding of CDs-based platforms for optimizing RES delivery and therapeutic application is necessary. This review highlights the physicochemical basis of the CDs-RES interaction, the mechanisms underlying improved bioavailability, and the effectiveness of CDs-based systems in both in vitro and in vivo models. Moreover, current challenges and future perspectives are discussed to highlight the potential of CDs-enabled strategies for optimizing RES delivery and therapeutic performance.

Full Text

Full text is available at the source.

View Full Text ↗

Funding

Competing interests

No financial or personal ties reported.

PubMed

Recent progress and potential treatments using cyclodextrin to deliver resveratrol

Abstract

Full Text

Funding

Competing interests

You found one interesting study. We’ll send the next 7.

What Lands in Your Inbox Each Week:

Recent issues from the longevity & aging brief