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Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells
Glioblastoma cells resist killing and keep releasing inflammatory signals despite lower immune activation after attack by natural killer cells
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Abstract
Natural killer (NK) cells showed decreased ability to kill brain cancer stem-like cells, leading to potential tumor growth inadequacy.
- Brain cancer stem-like cells and poorly differentiated glioblastoma multiforme showed increased resistance to NK cell lysis when differentiated by split anergized NK supernatants.
- Differentiation of these cells was associated with higher expression of CD54, B7H1, and MHC-I.
- The resistance to NK cells and the differentiation of brain cancer stem-like cells were mediated by interferon (IFN)-γ and tumor necrosis factor (TNF)-α.
- These brain cancer cells expressed low levels of tumor necrosis factor receptors and IFN-γ receptors.
- Increased secretion of interleukin (IL)-6 and chemokine IL-8 was observed in the presence of decreased IFN-γ secretion during NK cell interaction.
- NK-induced differentiation of brain cancer stem-like cells was independent of the functions of IL-6 and IL-8.
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