Biochemical and biophysical research communicationsMay 13, 2022

D-Allulose works with a gut hormone to activate appetite-controlling brain cells and reduce eating in mice

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗

Updated Apr 6, 2026

Abstract

D-Allulose administration at 5.6, 16.7, and 56 mM significantly increased calcium concentrations in hypothalamic arcuate nucleus neurons.

D-Allulose may enhance glucose and energy metabolism and reduce obesity.
Central injection of D-Allulose significantly decreased food intake in mice at 1 and 2 hours post-injection.
Approximately 40% of D-Allulose-responsive neurons also responded to glucagon-like peptide-1 with increased calcium levels.
D-Allulose activated calcium increases in 33% of proopiomelanocortin neurons in the hypothalamic arcuate nucleus.
D-Allulose could potentiate the action of glucagon-like peptide-1 in regulating feeding behavior.

Simplified

A rare sugar D-Allulose has sweetness without calorie. Previous studies have shown that D-Allulose improves glucose and energy metabolism and ameliorates obesity. However, underlying mechanisms remain elusive. This study explored the effect of central injection of D-Allulose on feeding behavior in mice. We also examined direct effects of D-Allulose on the neurons in the hypothalamic arcuate nucleus (ARC) that regulate feeding, including the anorexigenic glucagon-like peptide-1 (GLP-1)-responsive neurons and proopiomelanocortin (POMC) neurons. Single neurons were isolated from ARC and cytosolic Caconcentration ([Ca]) was measured by fura-2 microfluorometry. Administration of D-Allulose at 5.6, 16.7 and 56 mM concentration-dependently increased [Ca]in ARC neurons. The [Ca]increases took place similarly when the osmolarity of superfusion solution was kept constant. The majority (40%) of the D-Allulose-responsive neurons also responded to GLP-1 with [Ca]increases. D-Allulose increased [Ca]in 33% of POMC neurons in ARC. D-Allulose potentiated the GLP-1 action to increase [Ca]in ARC neurons including POMC neurons. Intracerebroventricular injection of D-Allulose significantly decreased food intake at 1 and 2 h after injection. These results demonstrate that D-Allulose cooperates with glucagon-like peptide-1 and activates the ARC neurons including POMC neurons. Furthermore, central injection of D-Allulose inhibits feeding. These central actions of D-Allulose may underlie the ability of D-Allulose to counteract obesity and diabetes. 2+ 2+ 2+ 2+ 2+ 2+ 2+ i i i i i i

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D-Allulose works with a gut hormone to activate appetite-controlling brain cells and reduce eating in mice

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