Decreased Risk of Readmission and Complications With Preoperative GLP-1 Analog Use in Patients Undergoing Primary Total Joint Arthroplasty

Preoperative GLP-1 receptor analog use is associated with a 42% decreased risk of periprosthetic joint infection after total hip and knee arthroplasties.

• In a study involving 268,504 patients who underwent total hip arthroplasty and 386,356 patients who underwent total knee arthroplasty, 1,044 and 2,095 patients, respectively, used preoperative GLP-1 receptor analogs.
• After adjusting for demographic and clinical differences, GLP-1 receptor analog use was linked to a reduced 90-day risk of periprosthetic joint infection (2.1% versus 3.6%).
• The risk of readmission within 90 days was also lower in patients using GLP-1 receptor analogs (1.1% versus 2.0%).
• No significant differences were found in other postoperative outcomes between patients using GLP-1 receptor analogs and those who did not.

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