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Using advanced computer models to create mRNA sequences that translate better and last longer
Updated
Abstract
GEMORNA-designed full-length mRNAs exhibited up to a 41-fold increase in firefly luciferase expression compared with an optimized benchmark.
- The generative RNA model is based on transformer architectures tailored for mRNA coding sequences and untranslated regions.
- Therapeutic mRNAs generated by GEMORNA achieved up to a 15-fold enhancement in human erythropoietin expression.
- GEMORNA substantially elicited antibody titers of a COVID vaccine in mice.
- The model also enhanced circular mRNA expression, boosting antitumor activity in chimeric antigen receptor T cells.
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