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Abstract
Aberrant aggregation of proteins is associated with neuroinflammation and cognitive decline.
- Specific proteins like amyloid beta and tau aggregate in the brain, contributing to neurodegenerative diseases.
- Dysregulation of protein homeostasis may lead to increased toxic protein accumulation.
- Degrons, short amino acid sequences, are crucial for targeting proteins for degradation.
- Alterations in degron sequences can disrupt protein homeostasis and enhance neural toxicity.
- The review discusses the potential of degron-targeting techniques as therapeutic strategies for various neurodegenerative diseases.
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