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DEL-1 is a natural protein that may reduce bone loss linked to aging cells
Updated
Abstract
Essence
DEL-1 functions as a secreted senolytic signal that may limit senescent stromal cells and senescence-associated bone loss.
Evidence
This preclinical cell and mouse study examined DEL-1 in senescent BM-MSCs, DEL-1-deficient and endothelial-overexpression mice, CD73-deficient models, and DEL-1 or macrolide treatment.
Caveat
The evidence is mechanistic and animal-based, with no human clinical test showing DEL-1 prevents senescence-associated bone loss.
Simplified
Longevity & Aging