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Delayed clearance of cerebrospinal fluid tracer from choroid plexus in idiopathic normal pressure hydrocephalus
Slower removal of fluid tracer from the brain's fluid-producing area in normal pressure hydrocephalus
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Abstract
The peak difference in normalized T1 signals between healthy individuals and those with idiopathic normal pressure hydrocephalus occurred after 24 hours.
- Impaired clearance of amyloid-β from the choroid plexus may contribute to amyloid deposition in Alzheimer's disease.
- A cerebrospinal fluid tracer, gadobutrol, was used to assess metabolic waste clearance in individuals with idiopathic normal pressure hydrocephalus.
- Normalized T1 signal increased to maximum within the choroid plexus and cerebrospinal fluid of lateral ventricles 6-9 hours after gadobutrol administration in both cohorts.
- Evidence suggests that gadobutrol is resorbed from cerebrospinal fluid by the choroid plexus, but this process is delayed in patients with idiopathic normal pressure hydrocephalus.
- The role of the choroid plexus in the pathogenesis of idiopathic normal pressure hydrocephalus regarding delayed clearance of amyloid-β remains uncertain.
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