Frontiers in public healthOct 17, 2026

Possible links between genetic risk for dementia and self-reported thinking problems after COVID

Long Covid Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Oct 18, 2026

Abstract

Dementia-related genetic risk factors may influence subjective cognitive complaints in individuals experiencing long COVID.

Persistent cognitive complaints, such as issues with attention and memory, are reported in some individuals with long COVID.
There is variability in cognitive symptoms among those with post-acute sequelae of SARS-CoV-2 infection.
Host genetic factors could play a role in the susceptibility to cognitive difficulties after COVID-19.
The study investigated the association between genetic risk scores for dementia and cognitive complaints following COVID-19.

Simplified

Coronavirus disease 2019 (COVID-19) may be associated with persistent subjective cognitive complaints, including difficulties with attention, memory, and executive function, in some individuals with post-acute sequelae of SARS-CoV-2 infection (PASC, "long COVID"). Inter-individual variability raises the possibility that host genetic factors contribute to susceptibility. This study explored the relationship between dementia-related polygenic risk scores (PRS) and subjective cognitive burden after COVID-19.

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Possible links between genetic risk for dementia and self-reported thinking problems after COVID

Abstract

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