Ketamine reduces overactivity in the brain’s emotion control center linked to depression

Ketamine's antidepressant effects often appear twenty-four hours after a single dose.

• The activation of the habenula may decrease during the time when ketamine's effects are observed.
• Reductions in aversive learning could be linked to the timing of ketamine's antidepressant effects.
• Evidence suggests that these changes occur in healthy subjects.

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