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Detection of Glymphatic Outflow of Tau from Brain to Cerebrospinal Fluid in Mice
Tracking the flow of tau protein from the brain to spinal fluid in mice
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Abstract
The glymphatic system may be responsible for eliminating extracellular tau from the brain to cerebrospinal fluid.
- Glymphatic flow involves the movement of brain interstitial fluid and cerebrospinal fluid through perivascular spaces.
- Cerebral arterial pulsation is a key driver of glymphatic convective flow.
- Aquaporin-4, a water channel, plays a crucial role in facilitating this process.
- Extracellular tau is physiologically released into extracellular fluids and can indicate clearance from the brain.
- Recent findings suggest that the glymphatic system may be involved in the elimination of extracellular tau.
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