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Abstract
Mitochondrial quality control is essential for maintaining cellular and tissue homeostasis.
- Mitophagy is the selective removal of damaged mitochondria that plays a crucial role in cellular health.
- Defects in mitophagy are linked to conditions such as neurodegeneration, cardiovascular disease, cancer, and mitochondrial disorders.
- Ubiquitin-dependent tagging is a key mechanism for identifying damaged mitochondria for degradation.
- Mitochondrial deubiquitinases (DUBs) influence the signaling process that marks damaged mitochondria, affecting their turnover.
- DUBs serve as context-dependent regulators of the mitochondrial ubiquitin code, connecting mitophagy to disease mechanisms.
- Emerging pharmacological strategies aim to develop therapeutics that target mitophagy for potential disease intervention.
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