Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

How the Body’s Internal Clock and Bmal1 Protein May Influence Diabetic Kidney Disease

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Circadian disruption in diabetic kidney disease (DKD) is associated with abnormal rhythms in blood glucose, lipids, and pressure.

  • Circadian rhythms play a significant role in the progression of diabetic kidney disease.
  • The core clock gene BMAL1 is linked to processes such as urinary protein excretion and irregular blood pressure in DKD.
  • Interactions between BMAL1, Sirt1, and NF-κB may influence mechanisms underlying DKD.
  • Novel pharmacological and behavioral strategies could be developed to address circadian rhythm disturbances in DKD.
  • The review highlights potential molecular targets related to circadian rhythms for future DKD research.

Simplified

Full Text

Full text is available at the source.
View Full Text ↗

Funding

Competing interests

Declaration of Competing Interest There are no potential conflicts of interest among the authors with respect to the research, authorship, and publication of this article. Competing Interests Neither the authors nor collaborators have any known competing financial interests or personal relationships that might have influenced this research.
PubMed

Related papers

Feb '22
BMAL1 Controls the Daily Pattern of Colitis Symptoms
top 10% journal
cited by 29 papers
research support, non-u.s. gov't
Nov '21
NF-κB influences the body’s daily clock by interacting with the main clock protein BMAL1
top 5% journal
cited by 85 papers
research support, n.i.h., extramural
Sep '15
A New Bmal1 Gene Mutation in Mice Shows the C-Terminal Part Is Crucial for Body Clock Rhythms
top 30% journal
cited by 21 papers
research support, non-u.s. gov't
Jan '14
How internal body clocks control daily changes in mouse liver insulin sensitivity through SIRT1
top 1% journal
cited by 135 papers
research support, non-u.s. gov't
Apr '16
Muscle insulin sensitivity in male mice is influenced by internal clock proteins through SIRT1
top 10% journal
cited by 79 papers
research support, non-u.s. gov't

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #47
Your body clock controls liver fibrosis — and scientists just found the on/off switch
yesterday7 studies
issue #46
Night shift workers' metabolomes fall out of sync — and glucose pays the price
1 week ago7 studies
issue #45
80% of FDA-approved drug targets show clock-dependent activity — timing may be everything
2 weeks ago7 studies
issue #44
Sleeping late on weekends is independently linked to higher cardiovascular disease risk
3 weeks ago7 studies
issue #43
A smartphone app cut mood episode recurrence 3.4x in people with depression and bipolar disorder
4 weeks ago7 studies
issue #42
Morning cancer immunotherapy linked to 49% vs 40% disease control rate in 969 patients
5 weeks ago7 studies
issue #41
Timing cancer treatment before 3pm nearly doubled survival in lung cancer patients
6 weeks ago7 studies
issue #40
Male mice lived 12% longer when they ate only during an 8-hour window at night
7 weeks ago7 studies
issue #38
Emergency doctors had 67% higher odds of chronic pain when working evening shifts vs. morning shifts
9 weeks ago7 studies
issue #36
Night owls show 77% higher risk of job burnout among firefighters
11 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief