Dietary ginsenosides for longevity: from biosynthesis and bioactive potential to functional food applications

Apr 7, 2026Critical reviews in food science and nutrition

Ginsenosides in food: their production, health benefits, and use for longer life

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Longevity & Aging on OpenScience ↗PubMed ↗DOI ↗

Abstract

Ginsenosides are associated with notable anti-aging properties and multi-target interventions.

Mitochondrial dysfunction and oxidative stress are key drivers of aging.
Ginsenosides may regulate cellular aging processes and support mitochondrial function.
Intestinal flora homeostasis could be influenced by ginsenosides.
Biosynthesis strategies may facilitate the industrial production of ginsenosides for functional foods.
Structural modifications and AI-driven delivery systems are used to improve ginsenoside bioavailability.
An integrated approach is proposed for using ginsenosides in managing aging-related health burdens.

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Ginsenosides, a class of bioactive substances, exhibit multi targets and notable anti-aging properties. However, their application as functional food ingredients is still limited. This review begins by examining the research advancements related to key drivers of aging, including mitochondrial dysfunction and oxidative stress. By integrating data from network pharmacology and molecular docking, it systematically reviews the intervention effects of ginsenosides on aging mechanisms that the regulation of cellular senescence and the maintenance of mitochondrial function and intestinal flora homeostasis. Biosynthesis strategies provide a viable pathway for the industrial production of ginsenosides and the development of functional foods. Furthermore, structural modifications combined with targeted delivery systems, supported by AI, have been strategically employed to enhance bioavailability and unlock their full bioactive potential as functional food ingredients. This work highlights the necessity of dietary ginsenosides in aging management based on the health burden of aging, and proposes an integrated strategy covering biosynthesis, mechanisms, AI-driven delivery applications and safety verification. It provides a comprehensive perspective on ginsenosides as functional food ingredients for evidence-based aging management.

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Dietary ginsenosides for longevity: from biosynthesis and bioactive potential to functional food applications

Abstract

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