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Abstract
Dietary interventions like caloric restriction (CR) and dietary restriction (DR) may significantly delay brain aging and reduce the risk of neurodegenerative diseases.
- CR and DR may modulate gene expression and alter epigenetic modifications that impact brain health.
- These dietary approaches could regulate protein maintenance and the process of removing damaged cellular components.
- Inhibition of neuroinflammation by CR and DR is associated with delaying age-related inflammation.
- Improvement in mitochondrial function and balance of oxidative stress may result from CR and DR.
- Optimization of nutrient-sensing pathways and metabolism is linked to the protective effects of CR and DR.
- Despite encouraging preclinical evidence, clinical application faces challenges such as individual differences and safety concerns.
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