How important is dietary management in chronic kidney disease progression? A role for low protein diets

Jun 21, 2021The Korean journal of internal medicine

How low-protein diets may slow the progression of chronic kidney disease

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Abstract

High dietary protein intake may lead to increased intraglomerular pressure and glomerular hyperfiltration, potentially aggravating chronic kidney disease (CKD).

  • A low protein diet (LPD) of 0.6 to 0.8 g/kg/day is recommended to manage CKD.
  • Dietary protein restriction may slow the progression of CKD and delay the need for dialysis.
  • LPD can help control metabolic issues in CKD, including metabolic acidosis and hyperphosphatemia.
  • A plant-dominant low-protein diet (PLADO), containing over 50% plant-based sources, may alleviate uremic burden and metabolic complications more effectively than diets high in animal protein.
  • PLADO may positively affect the gut microbiome, which could help reduce the generation of harmful uremic toxins and lower cardiovascular risk.
  • This diet may also relieve constipation, potentially decreasing the risk of hyperkalemia.

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