How low-protein diets may slow the progression of chronic kidney disease

High dietary protein intake may lead to increased intraglomerular pressure and glomerular hyperfiltration, potentially aggravating chronic kidney disease (CKD).

• A low protein diet (LPD) of 0.6 to 0.8 g/kg/day is recommended to manage CKD.
• Dietary protein restriction may slow the progression of CKD and delay the need for dialysis.
• LPD can help control metabolic issues in CKD, including metabolic acidosis and hyperphosphatemia.
• A plant-dominant low-protein diet (PLADO), containing over 50% plant-based sources, may alleviate uremic burden and metabolic complications more effectively than diets high in animal protein.
• PLADO may positively affect the gut microbiome, which could help reduce the generation of harmful uremic toxins and lower cardiovascular risk.
• This diet may also relieve constipation, potentially decreasing the risk of hyperkalemia.

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