Metabolism: clinical and experimentalOct 28, 2025

Benefits and drawbacks of different diets for treating fatty liver disease linked to metabolism

Regenerative Health Weekly Brief ↗PubMed ↗DOI ↗

Updated Jan 7, 2026

Abstract

Up to 33% of the global population is affected by metabolic dysfunction-associated steatotic liver disease (MASLD).

An altered lifestyle, marked by increased physical inactivity and high caloric food intake, is linked to the development of MASLD.
The optimal dietary pattern for treating MASLD remains uncertain and is a topic of ongoing debate.
Various dietary patterns, such as the Mediterranean Diet, DASH, Low-Carb Diet, Ketogenic Diet, Low-Fat Diet, Vegetarian Diets, and Intermittent Fasting, are examined for their potential effects on MASLD.
The review assesses the advantages and limitations of these dietary approaches in relation to MASLD treatment and associated cardiometabolic risk factors.

Simplified

Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming the most prevalent hepatic disorder, affecting up to 33 % of the global population. An altered lifestyle, characterized by extended physical inactivity and increased consumption of highly caloric food, often low in nutritional value, is recognised as one of the main contributing factors for MASLD. Cornerstone for MASLD treatment is a healthy lifestyle, starting from diet. However, the most appropriate dietary pattern for the treatment of MASLD remains a subject of debate. The aims of this narrative review are therefore to explore the mechanisms through which nutrition influences MASLD pathogenesis and to evaluate different dietary patterns for MASLD treatment, highlighting their advantages and limitations. Multiple dietary patterns-including the Mediterranean Diet (MD), the Dietary Approaches to Stop Hypertension (DASH), the Low-Carb Diet (LCD), the Ketogenic Diet (specifically the Very Low-Calorie Ketogenic Diet, VLCKD), the Low-Fat Diet (LFD), Vegetarian Diets (VDs), and Intermittent Fasting (IF)-are reviewed, with a focus on their efficacy on MASLD and the ameliorating of the associated cardiometabolic risks factors (CMRF).

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Declaration of competing interest The authors have no conflicts of interest to disclose.

PubMed

Benefits and drawbacks of different diets for treating fatty liver disease linked to metabolism

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