How dietary propionate affects fructose-related changes in fat metabolism, gut bacteria, and short-chain fatty acids in mice

Mice fed a 40% fructose diet showed higher levels of propionate and butyrate in circulation compared to those on a 0% fructose diet.

• Diet-induced steatosis was observed in mice consuming a 40% fructose diet.
• These mice exhibited a reduction in specific gut bacteria, including small intestinal proteobacteria and colonic actinobacteria.
• Propionate treatment did not affect liver or plasma lipid levels.
• Circulating levels of short-chain fatty acids (SCFAs) were unchanged by propionate treatment.
• Other bacterial groups were largely unaffected by propionate.

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