Dietary sulforaphane helps reduce stress-related depression and nerve damage by affecting the gut-brain connection

Dietary sulforaphane glucosinolate pretreatment reduced stress-linked depression-like behavior and corpus callosum demyelination in mice.

This preclinical mouse experiment gave C57BL/6 mice an 8-week 0.1% SGS-supplemented diet before 14 days of chronic restraint stress and measured behavior, myelin staining, MBP immunofluorescence, 16S gut microbiota profiles, and plasma metabolomics.

The findings come from a preventive mouse model with microbiota-metabolite correlations, so they do not establish human clinical benefit or prove the gut-brain pathway as the causal mechanism.