The Journal of pharmacy and pharmacology

Using diethylene glycol monoethyl ether as a new solvent for making mRNA lipid nanoparticles

Updated

Abstract

Diethylene glycol monoethyl ether (DEGEE) is evaluated as an alternative organic solvent for mRNA lipid nanoparticle production.

  • DEGEE may serve as a suitable substitute for ethanol in the manufacturing process.
  • The use of DEGEE could affect the properties of the resulting lipid nanoparticles.
  • Evaluating DEGEE's performance may provide insights into optimizing mRNA delivery systems.

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