Excessive use of social media (SM) platforms and digital technology (DT), often driven by habitual scrolling due to adaptive feed experiences, has been linked to anxiety, sleep disturbances, and obsessive-compulsive behaviors while also exacerbating mental health concerns. Yet, the role of "digital detox", defined as a voluntary reduction or temporary cessation of device use, remains only partially understood as both a clinical and lifestyle intervention. This comprehensive scoping review was conducted to consolidate existing research on digital detox interventions and evaluate contextual factors that may influence their effectiveness for mental health and well-being. A targeted keyword search for "digital detox" was conducted in the PubMed database on December 12, 2024, yielding 34 initial results. This review followed the approach recommended by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) to identify, screen, and extract evidence from relevant studies as per pre-specified inclusion criteria. A total of 14 studies were found eligible, and data from these studies and their relevant references (totaling 640 citations) were extracted and synthesized. Our findings suggest that digital detox interventions may alleviate depression and problematic internet use, and individuals with higher baseline symptom severity appear to derive higher benefits. However, the impact on broader outcomes such as life satisfaction and overall well-being remains variable. Divergent intervention approaches, ranging from short-term SM abstinence to sustained, moderate device restrictions and individual differences in baseline severity of symptoms, coping styles, environmental pressures, and support systems, may contribute to different outcomes across various studies and systematic reviews. Overall, age, gender, baseline mental health, and range and duration of DT usage prior to detox are the key variables that may determine the effectiveness of digital detox interventions. Tailored DT usage in moderation, aligned with each individual's age, developmental stage, and academic needs, has greater benefits among younger populations, particularly adolescents and young adults, while mindful and regulated SM use is especially advantageous for female populations. However, other populations could also benefit, provided interventions address self-regulation challenges specific to adult lifestyles. Given the growing global prevalence of problematic smartphone use (PSU) and its documented comorbidity with psychiatric disorders, digital detox strategies have the potential to be integrated into clinical recommendations and policy initiatives. However, a framework for assessing intervention quality and long-term outcomes is essential.