Full text is available at the source.
Abstract
Lipidoids engineered for selective mRNA delivery to the spleen showed strong targeting efficiency.
- A series of 48 chemically distinct lipidoids were synthesized to enhance mRNA delivery.
- Certain lipidoids with tails H228, H226x, H246x, and H446x exhibited exceptional spleen-targeting capabilities.
- A secondary library of 36 lipidoids was screened to identify candidates with high potency and spleen selectivity.
- The lead candidate, DMA4-H228, successfully delivered ovalbumin mRNA to antigen-presenting cells.
- This delivery prompted interferon-α production and activation of antigen-presenting cells, which may inhibit tumor growth.
Simplified