International immunopharmacology

Diosgenin glucoside may support platelet production by promoting cell recycling through the AMPK/mTOR/ULK1 pathway

Updated

Abstract

Diosgenin glucoside (DG) may offer therapeutic efficacy against radiation-induced thrombocytopenia (RIT).

  • RIT is a significant complication of cancer radiotherapy that can limit treatment options.
  • DG was selected for its potential benefits using a deep learning virtual screening method.
  • The study explores both the effectiveness of DG and its underlying molecular mechanisms.

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