Disease-modifying strategies in primary tauopathies

Primary tauopathies are characterized by the abnormal aggregation of tau protein, leading to neuron degeneration.

• Tauopathies feature abnormal tau species that aggregate into filamentous deposits within neurons.
• Different areas of the brain degenerate during the disease progression, impacting language, behavior, and movement.
• Four major therapeutic targets are identified: post-translational modifications of tau, tau aggregation, protein homeostasis, and tau genetics.
• Some therapeutic strategies, such as immunization, are already in clinical development, while others are in early stages of exploration.
• The review discusses both opportunities and challenges in developing effective treatments for tauopathies.

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