Arthritis & rheumatology (Hoboken, N.J.)Mar 14, 2014

Imbalanced B cell levels in newly diagnosed giant cell arteritis and polymyalgia rheumatica

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Apr 2, 2026

Abstract

Patients with giant cell arteritis (GCA) or polymyalgia rheumatica (PMR) had decreased circulating B cells compared to healthy controls.

Patients newly diagnosed with GCA or PMR exhibited a reduction in circulating B cells compared to age-matched healthy controls.
B cell numbers rapidly recovered in treated patients with GCA and PMR in remission, without increased production from the bone marrow.
There was an inverse correlation between B cell numbers and levels of inflammatory markers such as erythrocyte sedimentation rates and C-reactive protein.
Decreased levels of tumor necrosis factor α-positive effector B cells were observed in newly diagnosed patients with GCA or PMR.
Following treatment, the number of effector B cells normalized, and these cells showed an increased ability to produce interleukin-6.
Few B cells were detected in temporal artery biopsy samples from patients with GCA.

Simplified

OBJECTIVE: Several lines of evidence indicate that B cells may be involved in the immunopathology of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR). This study was undertaken to examine the distribution of defined B cell subsets, including effector B (Beff) cells and regulatory B (Breg) cells, in patients with GCA and patients with PMR before and after corticosteroid treatment.

METHODS: Circulating B cells were analyzed in 34 newly diagnosed, untreated patients with GCA or PMR, and in 44 followup samples from patients with GCA or PMR who received corticosteroids for 2 weeks or 3 months. For comparison, 40 age-matched healthy controls and 11 rheumatoid arthritis (RA) patients were included. Serum BAFF levels were determined, and temporal arteries were studied by immunohistochemistry.

RESULTS: Patients newly diagnosed as having GCA or PMR, but not patients with RA, had decreased numbers of circulating B cells compared to healthy controls. B cell numbers recovered rapidly in treated patients with GCA and PMR in remission. This recovery was not achieved by compensatory hyperproliferation or enhanced bone marrow production. B cell numbers inversely correlated with erythrocyte sedimentation rates, C-reactive protein levels, and serum BAFF levels. Tumor necrosis factor α-positive Beff cells, but not interleukin-10 (IL-10)-positive Breg cells, were decreased in patients newly diagnosed as having GCA or PMR. Following treatment, circulating numbers of Beff cells normalized. The returning Beff cells demonstrated an enhanced capacity to produce IL-6. Few B cells were found in temporal artery biopsy specimens from GCA patients.

CONCLUSION: We show for the first time that the distribution of B cells is highly disturbed in GCA and PMR and that B cells likely contribute to the enhanced IL-6 response in both diseases.

Full Text

Full text is available at the source.

View Full Text ↗

Imbalanced B cell levels in newly diagnosed giant cell arteritis and polymyalgia rheumatica

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the longevity & aging brief