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Deciphering the diurnal rhythm regulating mechanism of flavin-containing monooxygenase 3 in mouse liver
Daily cycle control of a liver enzyme involved in drug metabolism in mice
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Abstract
Flavin-containing monooxygenase 3 mRNA and protein levels showed robust diurnal rhythms in mouse liver and cell lines.
- Diurnal variations in flavin-containing monooxygenase 3 expression are associated with changes in drug metabolism.
- In vitro studies revealed altered N-oxidation rates of procainamide corresponding to the enzyme's expression at different times.
- E4 promoter-binding protein 4 negatively regulates flavin-containing monooxygenase 3 expression in liver cell lines.
- Brain and muscle ARNT-like protein-1 positively influences the expression of flavin-containing monooxygenase 3.
- Transcriptional regulation involves E4 promoter-binding protein 4 binding to a specific element and brain and muscle ARNT-like protein-1 activating three distinct sites.
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