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Abstract
Accumulated errors in DNA methylation maintenance may lead to global decreases in DNA methylation and hypermethylation of tumor suppressor genes.
- Aging-related diseases, including cancer, are associated with increased DNA mutations and changes in epigenetic regulation.
- DNA methylation modifications and histone variant changes during aging have been observed in both mice and humans.
- Epigenetic clocks, which measure DNA methylation levels, are becoming useful for estimating biological age.
- Increased concentrations of histone variants are noted in aged cells, influencing transcription and genome stability.
- Understanding epigenetic modifications may open new avenues for delaying aging effects and developing cancer therapies.
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