Using DNA nanodevices to gather lysosomes near the cell nucleus to control their function

A nucleus-targeting DNA nanodevice successfully promoted perinuclear clustering of lysosomes.

• Lysosomes play a critical role in regulating various biological processes, particularly their positioning within cells.
• The designed nanodevice effectively anchored to the outer surface of lysosomal membranes.
• This repositioning of lysosomes to the perinuclear region significantly enhanced autophagic flux.
• Changes in the expression of autophagy-related genes were observed following lysosomal repositioning.
• The approach provides a platform to explore the effects of lysosomal positioning on cellular functions.

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