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Common DNA differences linked to aging-related changes in African populations
Updated
Abstract
Essence
Common genetic variation affected epigenetic age estimates in these African cohorts, and a -aware predictor reduced ancestry-related error.
Evidence
This methylation-genotype analysis studied 138 people from Baka, ‡Khomani San, and Himba cohorts while benchmarking published predictors and developing a meQTL-minimized model.
Caveat
The cohorts were small and limited to three populations, so links between variants, lower epigenetic age acceleration, healthspan, and longevity remain inferential.
Simplified
Key numbers
4.62 years
Mean Error for Heritable Predictors
Mean absolute prediction error for heritable predictors in African test samples.
4.25 years
Mean Error for Non-Heritable Predictors
Mean absolute prediction error for non-heritable predictors in African test samples.
3211
Significant Age Associations Identified
Total significant age associations identified across 355,103 .
Longevity & Aging