Co-delivery of doxorubicin and erlotinib through liposomal nanoparticles for glioblastoma tumor regression using an in vitro brain tumor model

Dual functionalized liposomes achieved approximately 52% tumor cell death in an in vitro brain tumor model.

• The developed liposomal delivery system is designed to enhance the transport of chemotherapeutics across the blood-brain barrier.
• Surface modification with transferrin allows for targeted delivery to glioma cells.
• The inclusion of a cell-penetrating peptide increases the internalization of doxorubicin and Erlotinib into tumor cells.
• In vitro studies indicated significantly higher apoptosis in glioblastoma cells treated with dual functionalized liposomes.
• Cellular uptake studies showed efficient internalization of drugs in glioblastoma and brain endothelial cells.

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