Dp71's role in holding water channels in place within brain support cells

A 70% reduction of aquaporin-4 channel distribution was observed in the macroglial pericapillary endfeet of mice lacking Dp71.

• Loss of the Dp71 protein in mice is linked to significant alterations in glial cell function.
• A 50% reduction in β-dystroglycan was noted alongside the loss of aquaporin-4 channels.
• The effects of Dp71 loss on aquaporin-4 distribution were not uniform, varying between capillaries and larger vascular structures.
• Remaining aquaporin-4 isoforms were identified in larger vessels, suggesting alternative mechanisms may preserve water regulation in these areas.
• These changes may disrupt water homeostasis and blood-brain barrier integrity, potentially contributing to cognitive impairments.

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