Full text is available at the source.
DPP-mediated TGFβ signaling regulates juvenile hormone biosynthesis by activating the expression of juvenile hormone acid methyltransferase
DPP-related TGFbeta signals control juvenile hormone production by turning on the enzyme that finalizes hormone synthesis
AI simplified
Abstract
TGFβ signaling is essential for regulating juvenile hormone (JH) biosynthesis by influencing the expression of jhamt, a key enzyme.
- Neuropeptides and neurotransmitters from the brain play a role in JH biosynthesis regulation.
- A genetic screen in Drosophila identified Tkv and Mad as necessary for JH-mediated suppression of broad expression in young larvae.
- TGFβ signaling enhances JH production by increasing jhamt expression.
- Dpp hypomorphic mutants showed early broad expression, indicating disrupted JH regulation.
- Pupal lethality in dpp mutants was partially alleviated by applying an exogenous JH agonist.
- Glutamate, through Nmdar1, is linked to dpp expression changes in the corpus allatum.
AI simplified