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How a specific cell cleanup process involving Drp1, Pink1, and Parkin may contribute to cisplatin damage in ear blood vessel support cells
Updated
Abstract
Overexpression of Drp1 in pericytes increased protein levels of Drp1, Pink1, Parkin, and LC3B.
- Cisplatin exposure is associated with impaired mitochondrial division and autophagy in cochlear pericytes.
- Increased co-localization of TOM20 and LC3B suggests enhanced mitophagy following Drp1 overexpression.
- Drp1 overexpression leads to reduced reactive oxygen species in pericytes.
- Mitochondrial membrane potential is improved with Drp1 overexpression, indicating better mitochondrial function.
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