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Abstract
DsbA-L, or GSTK1, regulates multiple cellular processes, including adiponectin assembly and cellular responses to metabolic stress.
- DsbA-L influences metabolic homeostasis by facilitating adiponectin multimerization.
- The protein is involved in maintaining the integrity of mitochondria-associated membranes and redox control.
- DsbA-L plays a role in mitophagy and reticulophagy, processes important for cellular health.
- Its effects are context-dependent, varying across different metabolic, fibrotic, immune, and cancer conditions.
- Viewing DsbA-L as a regulator of stress adaptability may explain its diverse functions and outcomes.
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