Efficacy and safety of duloxetine in the treatment of older adult patients with generalized anxiety disorder: a randomized, double‐blind, placebo‐controlled trial

Duloxetine treatment resulted in a mean change from baseline in Hamilton Anxiety Rating Scale scores of -15.9 compared to -11.7 for placebo at week 10.

• Older adults with generalized anxiety disorder (GAD) showed significant improvement in anxiety and functioning scores when treated with duloxetine compared to placebo.
• Duloxetine was associated with greater reductions in both Hamilton Anxiety Rating Scale scores and Sheehan Disability Scale global scores.
• Completion rates for the study were similar between the duloxetine (76%) and placebo (75%) groups.
• Treatment-emergent adverse events occurred in 5% or more of patients taking duloxetine, with rates higher than those in the placebo group for certain side effects.
• Commonly reported adverse events included constipation, dry mouth, and somnolence.

AI simplified