Safety and tolerability of duloxetine in the treatment of major depressive disorder: analysis of pooled data from eight placebo‐controlled clinical trials

May 25, 2005Human psychopharmacology

Safety and side effects of duloxetine in treating major depression: combined results from eight placebo-controlled trials

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Abstract

Duloxetine-treated patients experienced a 9.7% discontinuation rate due to adverse events compared to 4.2% for placebo.

The rates of serious adverse events were 0.3% for duloxetine and 0.6% for placebo, with no significant difference.
Nausea, dry mouth, constipation, insomnia, dizziness, fatigue, somnolence, increased sweating, and decreased appetite were the most common treatment-emergent adverse events for duloxetine, each occurring in over 5.0% of patients.
Duloxetine-treated patients exhibited a mean weight decrease of 0.5 kg, while placebo patients showed a mean increase of 0.2 kg.
Changes in blood pressure and heart rate were minimal, with low incidences of abnormal increases.
No significant differences were observed between duloxetine and placebo regarding potentially clinically significant laboratory values.

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OBJECTIVE: To examine the safety and tolerability of the antidepressant duloxetine across multiple studies for major depressive disorder (MDD).

METHOD: Safety data were integrated from the acute phases of eight double-blind, placebo-controlled trials in which patients were randomized to duloxetine (40-120 mg/d; n = 1139) or placebo (n = 777) for up to 9 weeks. This data set included all acute-phase clinical trials that formed the basis of the New Drug Application (United States) or European Union submission package for duloxetine in the treatment of MDD. Two studies included continuation phases in which acute treatment responders received duloxetine or placebo for an additional 26 weeks. Safety assessments included serious adverse event reports, rates of discontinuation, spontaneously reported treatment-emergent adverse events, changes in vital signs and laboratory values, and electrocardiograms.

RESULTS: The rates of serious adverse events for duloxetine- and placebo-treated patients were 0.3% and 0.6%, respectively (p = 0.282). Adverse events led to discontinuation in 9.7% of duloxetine-treated patients, compared with 4.2% of patients receiving placebo (p < 0.001). Treatment-emergent adverse events with an incidence for duloxetine > or = 5.0% and significantly greater than placebo were nausea, dry mouth, constipation, insomnia, dizziness, fatigue, somnolence, increased sweating and decreased appetite. Mean changes in blood pressure and heart rate were small, and the incidence of increases above normal ranges was low. Duloxetine-treated patients had a mean decrease in weight of 0.5 kg compared with an increase of 0.2 kg for patients receiving placebo (p < 0.001). No significant differences were found between duloxetine and placebo in the incidence of potentially clinically significant laboratory values at anytime while on treatment.

CONCLUSION: These results are consistent with those obtained previously from smaller pooled data sets, and suggest that duloxetine is safe and well tolerated in patients with MDD.

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Safety and tolerability of duloxetine in the treatment of major depressive disorder: analysis of pooled data from eight placebo‐controlled clinical trials

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