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Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats
Bypassing part of the small intestine reduces fatty liver disease in rats made obese by a Western diet
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Abstract
Duodenal-jejunal bypass significantly reduced serum glucose and insulin resistance in obese rats on a western diet.
- The WD SHAM group exhibited greater obesity, hyperglycemia, and insulin resistance compared to the control group.
- Rats undergoing duodenal-jejunal bypass showed decreased serum glucose levels and improved insulin sensitivity compared to sham-operated counterparts.
- DJB surgery normalized serum triglycerides and reduced triglyceride accumulation in the liver of the bypass group.
- No significant differences were observed in the protein expressions of hepatic ACC and FAS across all groups.
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