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Abstract
Reduced mechano-sensing in osteocytes accelerated whole-body aging in mice.
- Dynamic tibial axial loading (DTAL) extended the healthspan and lifespan of mice by 9.4% or 79.5 days.
- DTAL reversed bone marrow immunosenescence and promoted factors associated with anti-aging.
- Pro-aging and pro-inflammatory factors were downregulated following DTAL treatment.
- Pigment epithelium-derived factor (PEDF) was identified as a novel mechano-responsive anti-aging factor linked to healthy aging in humans.
- Bone mechano-sensing plays a crucial role in the aging process of the whole body.
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