The new DYRK1A blocker KVN93 may improve thinking, reduce amyloid-beta buildup, and lower brain inflammation

KVN93 treatment in 5x FAD mice significantly improved long-term memory and reduced Aβ plaque levels.

• KVN93 enhanced dendritic synaptic function, which is associated with improved long-term memory.
• Aβ plaque levels were significantly reduced by KVN93 through the regulation of Aβ degradation enzymes neprilysin and insulin-degrading enzyme.
• Microglial and astrocyte activation induced by Aβ was significantly suppressed in KVN93-treated 5x FAD mice.
• KVN93 altered neuroinflammation in microglial cells but not in primary astrocytes by modulating signaling pathways.
• In wild-type mice, KVN93 treatment reduced activation of microglia and astrocytes following LPS injection.

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