Disrupted daily rhythms in gut bacteria and tumor environment

Circadian dysfunction significantly impacts the newly proposed rhythms-microbiota-microenvironment axis.

• Alterations in circadian rhythms are linked to increased risks of tumor formation, growth, and metastasis.
• Dysfunction of circadian rhythms is associated with changes in the gut microbiota and tumor microenvironment.
• The review highlights the complex interactions between the circadian system, gut microbiota, and tumor microenvironment.
• Therapeutic strategies may be developed to normalize the tumor microenvironment by targeting the interplay between circadian rhythms and gut microbiota.

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