Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment

Jun 28, 2025Gut microbes

Disrupted daily rhythms in gut bacteria and tumor environment

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Abstract

Circadian dysfunction significantly impacts the newly proposed rhythms-microbiota-microenvironment axis.

Alterations in are linked to increased risks of tumor formation, growth, and metastasis.
Dysfunction of circadian rhythms is associated with changes in the and .
The review highlights the complex interactions between the circadian system, gut microbiota, and tumor microenvironment.
Therapeutic strategies may be developed to normalize the tumor microenvironment by targeting the interplay between circadian rhythms and gut microbiota.

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govern physiological activities through the precise modulation of gene expression and biochemical functions. Dysfunction of circadian rhythms is associated with an increased risk of tumor formation, growth, and metastasis, as well as alterations in the (GM) and the (TME). Indeed, the intricate regulatory interactions between the circadian system, GM, and TME present a promising area for further exploration. This review, centered on the circadian system, focuses on the dynamics in the GM and the TME driven by circadian dysfunction. Additionally, it places particular emphasis on the interplay between circadian rhythms and GM. The review further explores how this interplay can be therapeutically leveraged to normalize the TME and enhance clinical outcomes. For the first time, the rhythms-microbiota-microenvironment axis is proposed, linking the circadian system, GM, and TME. Circadian dysfunction significantly impacts this axis, leading to disruptions in both the GM and TME. The review also provides the latest insights and innovative therapies from the perspective of the interplay between circadian rhythms and GM.

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Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment

Abstract

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