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Abstract
Osteoarthritis is associated with both protective and detrimental effects of autophagy depending on disease stage and stress intensity.
- Autophagy plays a critical role in osteoarthritis by removing damaged cellular components.
- Excessive autophagy can lead to damage of cartilage cells (chondrocytes).
- Non-coding RNAs are involved in the regulation of autophagy in osteoarthritis.
- Autophagy interacts with various cell death pathways, including apoptosis and pyroptosis.
- Natural compounds and drugs targeting autophagy show potential for therapeutic use, but face challenges such as poor bioavailability.
- Future research may explore the interaction between autophagy and ferroptosis in osteoarthritis.
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