Journal of affective disordersOct 30, 2026

Psilocybin with psychological support may reduce loss of pleasure in hard-to-treat depression: A small controlled trial

Psychedelic Science Weekly Brief ↗PubMed ↗DOI ↗

Updated Nov 2, 2026

Abstract

Anhedonia is a core feature of major depressive disorder (MDD) that is frequently resistant to available treatments.

Psilocybin's specific efficacy for treating anhedonia is not well understood.
Major depressive disorder often presents challenges in treatment response.
Further exploration is needed to clarify the role of psilocybin in addressing anhedonia.

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