We can’t show the full text here under this license.
Fragments from broken elastin trigger aging by activating the innate immune system
Updated
Abstract
Essence
Elastin-derived extracellular matrix fragments may promote aging by activating innate immune signaling through NEU1.
Evidence
This mixed human, mouse, immune-humanized mouse, and pig study linked circulating ECM fragments with age, tested lifespan effects of elastin fragments, and found NEU1 inhibition extended lifespan by up to 17% in naturally aged mice.
Caveat
The strongest intervention evidence is preclinical, and the human data show correlations with aging indicators rather than demonstrated lifespan benefit from NEU1 inhibition.
Simplified
Key numbers
1,068
Cohort Size
Number of human participants studied for correlations with elastin fragment levels.
17%
Lifespan Extension
Percentage increase in lifespan observed in mice treated with the inhibitor DANA.
Longevity & Aging