The Elongator complex regulates hypocotyl growth in darkness and during photomorphogenesis

Jul 20, 2017Journal of cell science

The Elongator complex controls stem growth in the dark and during light-driven development

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Abstract

Elongator complex mutants exhibit defective hypocotyl elongation while maintaining a normal apical hook in darkness.

Elongator influences growth, development, and responses to environmental stressors such as drought.
Mutants show altered transcript levels, including downregulation of genes related to the circadian clock and photomorphogenesis.
Histone H3K14 acetylation by Elongator targets specific genes in darkness.
Elongator may modulate the plant immune response and promote growth through transcriptional regulation of key genes.

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The Elongator complex (hereafter Elongator) promotes RNA polymerase II-mediated transcript elongation through epigenetic activities such as histone acetylation. Elongator regulates growth, development, immune response and sensitivity to drought and abscisic acid. We demonstrate thatmutants exhibit defective hypocotyl elongation but have a normal apical hook in darkness and are hyposensitive to light during photomorphogenesis. Thesephenotypes are supported by transcriptome changes, including downregulation of circadian clock components, positive regulators of skoto- or photomorphogenesis, hormonal pathways and cell wall biogenesis-related factors. The downregulated genes,andare selectively targeted by Elongator for histone H3K14 acetylation in darkness. The role of Elongator in early seedling development in darkness and light is supported by hypocotyl phenotypes of mutants defective in components of the gene network regulated by Elongator, and by double mutants betweenand mutants in light or darkness signaling components. A model is proposed in which Elongator represses the plant immune response and promotes hypocotyl elongation and photomorphogenesis via transcriptional control of positive photomorphogenesis regulators and a growth-regulatory network that converges on genes involved in cell wall biogenesis and hormone signaling.This article has an associated First Person interview with the first author of the paper. elo elo LHY HFR1HYH elo

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The Elongator complex regulates hypocotyl growth in darkness and during photomorphogenesis

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