Two-Way Links Between Cell Membrane Transport Problems and Fat Metabolism Disorders

The endo-lysosomal system is a central regulator of intracellular trafficking and metabolic homeostasis.

• Disruption of the endo-lysosomal-lipid axis can impair endosomal maturation and lysosomal acidification.
• Defective cellular clearance and chronic inflammatory responses may result from dysfunction in the endo-lysosomal system.
• Cholesterol trafficking and lipid redistribution are affected by the dysfunction of the endo-lysosomal system.
• Secondary lipid accumulation and metabolic imbalance could arise from impaired macromolecular degradation.
• The review emphasizes the importance of membrane trafficking and lysosomal homeostasis in disease progression.

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